The top layer is the serum sample. Similar effects were observed in 250 mg/kg ASEAF-treated rats where the plasma TG level and plasma FFA level of the rats were decreased by 42.04% and 34.38%, respectively. The plant grows wild, but is also cultivated for food, herbal medicines, as an ornamental plant (red variety, as a hedging plant), in the aquarium trade (though it only grows submersed for short periods), and as poultry feed. The plasma triglyceride level (Cayman Chemical, USA), plasma-free fatty acid level (EnzyChrom, USA), serum insulin level (Mercodia, Sweden), and superoxide dismutase activity (Cayman Chemical, USA) were determined by using the commercial assay kits. Berberine is an inhibitor of dipeptidyl peptidase IV [3]. The mixture was subjected to sonication for 15 minute at room temperature. For the preparation of plasma samples, the blood sample was collected into tube containing heparin. Further studies are on the way to pile up more data and evidence in order to elucidate the molecular mechanism of action using both in vitro and in vivo methods. Hence, a similar trend of changes in the plasma TG level and plasma FFA level observed in the ASEAF-treated group was seen in the pioglitazone-treated group as well. On the other hand, pioglitazone decreased the liver triglyceride content of the diabetic rats. Last update on 2019-06-13: Now containing 11906 plants. Two phases were obtained, and the lower phase was evaporated. The leaves are used as a vegetable. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Synonyms. Briefly, the diabetic rats were divided into 5 groups () and were fasted overnight for 16 hours. This is because at a similar level of insulin in the blood of the diabetic rats in different groups, the fasting BGL of the treatment groups (ASEAF treated and pioglitazone treated) were lower, indicating that the decrease in BGL was brought about by the enhanced insulin action. The pink underside of the leaves of Alternanthera reineckii 'Pink' provides an effective contrast to the many green plants in an aquarium - particularly when planted in groups. The authors declare that there is no conflict of interests. Neutral: On Nov 22, 2006, frostweed from Josephine, Arlington, TX (Zone 8a) wrote: Sessile Joyweed Alternanthera sessilis is … Yin et al. Blood samples were collected from the tail vein. Pioglitazone improves peripheral insulin resistance by activating peroxisome proliferator-activated receptor-gamma (PPARγ). Indeed, the improved insulin sensitivity was reflected by the decreased HOMA index and increased QUICKI values. We are committed to sharing findings related to COVID-19 as quickly as possible. Figure 8 shows that the pancreatic total SOD activity of both ASEAF-treated group and pioglitazone-treated group was significantly higher than the negative control group (). On the next day, the diabetic rats in different groups were fed with 500 mg/kg fractions (hexane, ethyl acetate, and water), 30 mg/kg glibenclamide (positive control), and a dose volume of 2 mL/kg of 1% carboxymethylcellulose (CMC) prepared in distilled water (negative control), respectively. Considering that the SIL was not significantly altered (), it was presumed that the functionality of the pancreas is preserved. An OGTT curve was plotted, and the area under the curve was calculated using the trapezoid rule [12] as follows:
Kok Keong Tan, Kah Hwi Kim, "Alternanthera sessilis Red Ethyl Acetate Fraction Exhibits Antidiabetic Potential on Obese Type 2 Diabetic Rats", Evidence-Based Complementary and Alternative Medicine, vol. It is a widespread genus with most species occurring in the tropical Americas, and others in Asia, Africa, and Australia. Also, isolation and identification of the bioactive compound(s) that responsible for the antidiabetic effect are in progress. folkloric uses and medicinal studies. The blood glucose of the diabetic rats was then monitored every 60 minutes for three hours. Also, A. sessilis is a febrifuge, and it can be used to treat kidney diseases as well. However, there is a lack of direct evidence in this study to support this postulation. Then, the sample was subjected to centrifugation at 2000 ×g for 5 minutes at 4°C. This cultivar is more commonly found in Malaysia and Singapore than the wild type. After treatment with 30 mg/kg pioglitazone, the plasma TG level, and plasma FFA level of the treated rats decreased 52.21% and 35.57%, respectively. The plant is bitter, sweet, constipating and cooling in action. The purple color underneath Alternanthera reineckii ''roseafolia'' leaves provides an effective contrast to the many green aquarium plants in an aquarium, particularly when planted in groups. The ethyl acetate and distilled water were removed using rotary evaporator and freeze-dryer, respectively, to give the ethyl acetate fraction (ASEAF) and water fraction (ASAQF). The supernatant was transferred into a new centrifuge tube and stored at −20°C, while the pellet was subjected to extraction again. We demonstrated that ASEAF possesses antihyperglycemic effect, antitriglyceridemic effect, and pancreatic protective effect in obese type 2 diabetic rats. Distribution in Canada. Rather, it improved the peripheral insulin sensitivity. Terpenoids are known to possessed antioxidative capacity [23]. Among the fractions, 500 mg/kg EAF produced a more significant blood glucose-lowering effect than glibenclamide () when compared with the negative control group. Alternanthera sessilis [sessile joyweed (SJ)] is a staple leafy vegetable in Sri Lanka. HXF and AQF did not show significant antihyperglycemic effect in this experiment (). Alternanthera sessilis Red ethyl acetate fraction (ASEAF) was found to possess the most potent antihyperglycemic effect through oral glucose tolerance test. After the injection of STZ, the rats were given 5% glucose solution for 24 hours to prevent hypoglycemia. Show More About 0.2 g of thawed pancreas portion was homogenized in 5.0 mL of cold 20 mM HEPES buffer, pH 7.2. Type 2 diabetes mellitus (T2D) is a group of metabolic disorders that affect more than 90% of the diabetes population. #Amaranthaceae Seed/Fruit type. Amaranthaceae. sessile joyweed. It is a pest of sugarcane, a weed of rice in tropical areas, and an agricultural weed that. Murase et al. It has sturdy red/purple stems and long pointy leaves. On the other hand, the crude ethanol extract showed blood glucose lowering effect in the preliminary study carried out in our lab. The superoxide dismutase activity was expressed as unit/mg wet tissue. Seemai Ponnangkanni, which is red in color, is often grown for its beauty. It could be considered a ground cover in many circumstances. The antidiabetic potential of Alternanthera sessilis Red was investigated using the obese type 2 diabetic rats induced by high fat diet and streptozotocin. Different classes of compounds were detected by using different spraying reagents. The TLC plate was then allowed to develop in a chamber saturated with ethyl acetate and chloroform in the ratio of 6 : 4 (ethyl acetate : chloroform). Male Sprague-Dawley (SD) rats weighed between 200–230 g were obtained from the Laboratory Animal Centre, Faculty of Medicine, University of Malaya. To get this best colours out of this plant, high light is required which can often make this tricky to grow. Red Sessile Joyweed, red carpet weed, dwarf copperleaf, keremak merah, 莲子草 , lian zi cao, Pictures, scientific name, common name and origin of flora of Malaysia My Tropical Plants Finder: Alternanthera sessilis 'Red' Subsequently, 2 g/kg glucose solution (dissolved in distilled water) was administered to all the diabetic rats. ASEAF was dissolved in dichloromethane and spotted on a thin-layer chromatography (TLC) plate. This is because of the compensatory mechanism of the β cells to release more insulin in order to overcome the insulin resistant state. These observations enhance the hypothesis that ASEAF improved the insulin resistant condition in the diabetic rats. Growth Form. Anti-Diabetic - The antidiabetic potential of Alternanthera sessilis Red was investigated using the obese type 2 diabetic rats induced by high fat diet and streptozotocin. Stems are smooth and reddish purple. When insulin resistance is developed, a vicious cycle takes place, whereby lipid metabolism will be deranged, and more FFA will be produced. (Alternanthera sessilis) aka Mukunuwenna, Dwarf Copperleaf, Red Carpet Weed Perennial Full sun - part shade Edible Prefers shallow water Small white sessile spike flowers If it is in season and available in WA it is in stock. Good light encourages the leaves to turn red. [10] with slight modification. B. Jenkins, E. A. Daley, D. J. Chisholm, and L. H. Storlien, “Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats,”, G. Boden, P. She, M. Mozzoli et al., “Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-, L. C. Bollheimer, R. H. Skelly, M. W. Chester, J. D. McGarry, and C. J. Rhodes, “Chronic exposure to free fatty acid reduces pancreatic, J. Graßmann, “Terpenoids as plant antioxidants,”. Available ... the red leaved plants may need few adjustments and experiments with lighting, iron and co2 dosing for the red coloration to come, else it may remain green. Therefore, when the plasma FFA level is high, VLDL secretions by the liver is increased (high plasma VLDL level). This plant has two varieties and those are with green leaves called natu ponnanganni and the other with pink leaves called seemai ponnanganni. Perennial herb up to 10-45 cm tall with a prostrate growth habit. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Alternanthera Sessilis. Alternanthera Sessilis. Alternanthera is a genus of flowering plants in the family Amaranthaceae.
Alternanthera sessilis "Red" is an aquatic plant known by several common names, including sessile joyweed and dwarf copperleaf.
If you would like to support this site, please consider, Plants can form a dense carpet of growth. Easy to propagate by nipping off the terminal bud and planting it in the substrate. The blood glucose lowering effect of the fractions was determined by oral glucose tolerance test (OGTT) [11]. The residual was dissolved in 0.5 mL of isopropanol which contained 10% Triton X-100 before subjected to the triglyceride assay using the assay kit. Fruits. All animals were acclimatized for one week before any experimental procedures, and all experimental procedures were approved by the animal ethical committee of University of Malaya (Ethic number: FIS/27/01/2010/TKK (R)). Narrow, elongated leaves are reddish purple with entire leaf margin (smooth edges). There is A. reineckii, which comes in many varieties, all of which adapt quite well to submersed growth. The organs harvested were washed with saline solution and stored at −80°C until used. The mixture was subjected to centrifugation at 3000 rpm for 5 minutes at 4°C. How Alternanthera Sessilis is effective for various diseases is listed in repertory format. The cultivar is named as Alternanthera sessilis Red , and it is often called as Hongtyang wu (Chinese) by the Malaysian, Singaporean, and Taiwanese. Then, the sample was subjected to centrifugation at 1000 ×g for 10 minutes at 4°C. A decoction of A. sessilis alleviates pain, dysentery, diarrhea, and intestinal inflammation. Plasma FFA level has been known to cause hepatic insulin resistance [21]. This plant and the related entity italicized and indented above can be weedy or invasive according to the authoritative sources noted below.This plant may be known by one or more common names in different places, and some are listed above. 2013, Article ID 845172, 8 pages, 2013. https://doi.org/10.1155/2013/845172, 1Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. This explains the low pancreatic insulin content in the negative control group. The insulin sensitivity indexes (HOMA and QUICKI) were used to quantify the effect. The rats were housed in the animal room in Department of Physiology, Faculty of Medicine, University of Malaya, under standard environmental conditions, relative humidity, and dark/light cycle. The aerial parts of ASR were dried in the oven at 40°C and crushed into powder. Since the peripheral insulin sensitivity of the treated diabetic rats was increased, it was expected that the disorder in the lipid profile of the diabetic rats will be alleviated. Stems becomes 25-50 cm tall. Three fractions (hexane, ethyl acetate, and water) were obtained from the crude ethanol extract of Alternanthera sessilis Red. The liver abstracts more FFA when the FFA concentration in the blood increases. Flowers. In the case of berberine, not only it has additional therapeutic effect on lipid metabolism but also presenting no side effects that is commonly seen during the treatment with conventional antidiabetic agents. Flowers. Plasma and serum samples were prepared from the blood samples collected according to the instructions provided in the assay kits. Three fractions (hexane, ethyl acetate, and water) were obtained from the crude ethanol extract of Alternanthera sessilis Red. One kilogram of the powder was extracted with 3 L of 95% ethanol at room temperature for three days. One classic example is the alkaloid berberine. 413. Indeed, the plasma triglyceride (TG) level and plasma free fatty acid (FFA) level of the pioglitazone-treated group and ASEAF-treated group were significantly lower than the negative control group () as shown in Figures 4 and 5, respectively. Alternanthera sessilis. 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